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Redox-Neutral Site-Selective C–H Allylation and Iodolactonization of Benzoic Acids Using Morita–Baylis–Hillman Adducts in Water

Posted on 2023-09-08 - 13:37
A Ru-catalyzed carboxylate directed C–H allylation and iodolactonization of benzoic acids has been accomplished with Morita–Baylis–Hillman adducts as the coupling partner in environmentally benign water as solvent. The redox-neutral conditions, use of water as a solvent, substrate scope, functional group tolerance, and mutation of natural products and drug molecules are the important practical features.

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