Reactivity Control of Polymer Functional Groups by
Altering the Structure of Thermoresponsive Triblock Copolymers
Posted on 2019-09-24 - 08:29
A thermoresponsive ABA triblock copolymer
bearing an aldehyde group
on the thermoresponsive A segments was synthesized. The polymer formed
a micellar assembly due to the hydrophobic interactions of the thermoresponsive
segment above the lower critical solution temperature (LCST). In contrast,
the ABA polymer assembly decomposed upon lowering the temperature
below the LCST. Using this structural change, the reactivity of the
aldehyde group toward primary amines of albumin and poly(allylamine)
was investigated. When the ABA polymer assembly and reactant were
mixed above the LCST, Schiff base formation was suppressed because
of the aldehyde group being protected by the hydrophobic thermoresponsive
core. In contrast, Schiff base formation between the ABA triblock
copolymer and the primary amine moiety on the molecules was confirmed
below the LCST. The reactivity of the aldehyde functional group can
therefore be controlled by altering the structure of the thermoresponsive
ABA polymer.
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Akimoto, Jun; Tamate, Ryota; Okazawa, Shingo; Akimoto, Aya M.; Onoda, Michika; Yoshida, Ryo; et al. (2019). Reactivity Control of Polymer Functional Groups by
Altering the Structure of Thermoresponsive Triblock Copolymers. ACS Publications. Collection. https://doi.org/10.1021/acsomega.9b01816
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AUTHORS (7)
JA
Jun Akimoto
RT
Ryota Tamate
SO
Shingo Okazawa
AA
Aya M. Akimoto
MO
Michika Onoda
RY
Ryo Yoshida
YI
Yoshihiro Ito