REDOX Responsive Fluorescence Active Glycopolymer
Based Nanogel: A Potential Material for Targeted Anticancer Drug Delivery
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Posted on 2019-06-06 - 11:38
A well-defined glycopolymer based
fluorescence active nanogel has
been prepared via the combination of reversible addition–fragmentation
chain transfer (RAFT) polymerization and Diels–Alder (DA) “click”
chemistry. To prepare the nanogel, initially, a functional AB block
copolymer (BCP) poly(pentafluorophenyl acrylate)-b-poly(furfuryl methacrylate) (PPFPA-b-PFMA), having
activated pentafluorophenyl ester group, was synthesized via RAFT
polymerization. The activated pentafluorophenyl functionality was
replaced by the amine functionality of glucosamine to introduce the
amphiphilic BCP poly[2-(acrylamido) glucopyranose]-b-poly(furfuryl methacrylate) (PAG-b-PFMA). Furthermore,
the terminal acid (−COOH) functionality of the RAFT agent was
modified by gelatin QDs (GQDs) to generate fluorescence active glycopolymer.
An anticancer drug, Doxorubicin, was loaded in the micelle via the
successive addition of the drug molecule and cross-linking using dithio-bismaleimidoethane
(DTME), a REDOX responsive cross-linker. The anticancer activity of
the drug loaded nanogel was observed over MBA-MD-231, human breast
cancer cell line, and monitored via fluorescence spectroscopy and
flow cytometric analyses (FACS). The cytotoxicity of the prepared
glycopolymer based nanogel over the MBA-MD-231 cell line was assessed
via MTT assay test, and it was observed that the synthesized nanogel
was noncytotoxic in nature.
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Bhattacharya, Koushik; Banerjee, Sovan Lal; Das, Subhayan; Samanta, Sarthik; Mandal, Mahitosh; Singha, Nikhil K. (2019). REDOX Responsive Fluorescence Active Glycopolymer
Based Nanogel: A Potential Material for Targeted Anticancer Drug Delivery. ACS Publications. Collection. https://doi.org/10.1021/acsabm.9b00267