Pyrrolidine−Thiourea as a Bifunctional
Organocatalyst:  Highly Enantioselective
Michael Addition of Cyclohexanone to
Nitroolefins

Tang, Yong

Pyrrolidine−Thiourea as a Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins

Posted on 2006-07-06 - 00:00

Asymmetric Michael additions of cyclohexanone to both aryl and alkyl nitroolefins in the presence of 20 mol % of organocatalyst 2b and 10 mol % of n-butyric acid afford adducts 5 with high diastereoselectivities and enantioselectivities.

CITE THIS COLLECTION

Cao, Chun-Li; Ye, Meng-Chun; Sun, Xiu-Li; Tang, Yong (2016). Pyrrolidine−Thiourea as a Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins. ACS Publications. Collection. https://doi.org/10.1021/ol060481c

https://doi.org/10.1021/ol060481c

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