Pyrimidine Nucleosides from Streptomyces sp. SSA28

Ma, Zhong-Jun

Pyrimidine Nucleosides from Streptomyces sp. SSA28

Posted on 2019-08-22 - 14:36

Eleven new pyrimidine nucleosides (1–11) and 12 known analogues (12–23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2–16 were investigated by ECD calculations. Compounds 11–16 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC₅₀ values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.

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Xu, Cheng-Dong; Zhang, Hao-Jian; Ma, Zhong-Jun (2019). Pyrimidine Nucleosides from Streptomyces sp. SSA28. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.9b00260

https://doi.org/10.1021/acs.jnatprod.9b00260

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