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Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities

Posted on 2012-05-18 - 00:00
During process optimization of Escitalopram oxalate novel impurities, 6 and 7 were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved the yield and purity of the drug product during the bulk API synthesis.

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