Process Development of
Citalopram/Escitalopram Oxalate:
Isolation and Synthesis of Novel Impurities
Posted on 2012-05-18 - 00:00
During process optimization of Escitalopram oxalate novel
impurities, 6 and 7 were observed, which
were isolated and
characterized, and the proposed structure was confirmed by chemical
synthesis. Investigation of the cause of impurities formation improved
the yield and purity of the drug product during the bulk API synthesis.
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Pramanik, Chinmoy; Hivarekar, Raghvendra R.; Deshmukh, Sanjay S.; Tripathy, Narendra
K.; Kotharkar, Sandeep; Chaudhari, Ashok; et al. (2016). Process Development of
Citalopram/Escitalopram Oxalate:
Isolation and Synthesis of Novel Impurities. ACS Publications. Collection. https://doi.org/10.1021/op300039c