Polyelectrolyte Complex-Covalent Interpenetrating
Polymer Network Hydrogels
Posted on 2022-06-02 - 07:08
Polyelectrolyte
complex (PEC) hydrogels possess rich microstructural
diversity and tunability of the shear response, self-healing attributes,
and pH- and salt-responsiveness. Yet, their utility in biotechnology
and biomedicine has been limited, owing to their weak mechanical strength
and uncontrolled swelling. Here, we introduce a strategy to overcome
these drawbacks of PEC hydrogels by interlacing the electrostatically
crosslinked PEC network with a covalently crosslinked polymer network,
creating polyelectrolyte complex-covalent interpenetrating polymer
network (PEC-IPN) hydrogels. Structural and material characterizations
of model PEC-IPN hydrogels composed of oppositely charged ABA triblock copolymers and photocrosslinkable 4-arm poly(ethylene
oxide) (PEO) highlight the key advantages of our approach. Upon initial
mixing of the three constituents, the PEC network self-assembles swiftly
in aqueous environs, providing structural rigidity and serving as
protective scaffoldings for the covalently crosslinkable PEO precursors.
Photocrosslinking of the PEO chains creates a covalent network, providing
structural reinforcement to the PEC network. The resulting PEC-IPN
hydrogels possess significantly improved shear and tensile strengths,
swelling characteristics, and mechanical stability in saline environments
while preserving the intrinsic mesoscale structure of the PEC network
and its salt-responsiveness. We envision that our approach to fabricating
PEC-based IPN hydrogels will pave the way for the creation of self-assembled
hybrid materials that harness the unique attributes of electrostatic
self-assembly pathways, with broad applications in biomedicine.
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Li, Defu; Göckler, Tobias; Schepers, Ute; Srivastava, Samanvaya (2022). Polyelectrolyte Complex-Covalent Interpenetrating
Polymer Network Hydrogels. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.2c00590
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AUTHORS (4)
DL
Defu Li
TG
Tobias Göckler
US
Ute Schepers
SS
Samanvaya Srivastava
KEYWORDS
upon initial mixingintrinsic mesoscale structureassembled hybrid materialsweak mechanical strengthproviding structural rigidityproviding structural reinforcementpeo chains createscreating polyelectrolyte complexipn hydrogels composedbased ipn hydrogelspec network selfpolyelectrolyte complexmechanical stabilitypec networkcovalent networkpec hydrogelsunique attributesuncontrolled swellingtriblock copolymersthree constituentstensile strengthsswelling characteristicsshear responsesaline environmentsresulting pecprotective scaffoldingsphotocrosslinkable 4oppositely chargedmodel pecmaterial characterizationskey advantageshealing attributesfabricating pecelectrostatic selfbroad applicationsassembly pathwaysassembles swiftlyaqueous environsaba