Periconiasins A–C, New Cytotoxic Cytochalasans with an Unprecedented 9/6/5 Tricyclic Ring System from Endophytic Fungus Periconia sp.

Dai, Jungui

Periconiasins A–C, New Cytotoxic Cytochalasans with an Unprecedented 9/6/5 Tricyclic Ring System from Endophytic Fungus Periconia sp.

Posted on 2016-02-19 - 13:37

Periconiasins A–C (1–3), new cytochalasans with an unprecedented 9/6/5 tricyclic ring system, were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic and X-ray crystallographic analyses. Their biosynthesis is proposed to occur from an unusual seven acetate/malonate polyketide backbone attached to one leucine moiety by a PKS-NRPS followed by Diels–Alder and other reactions. 1 and 2 showed significant cytotoxicity against human HCT-8 cancer cells.

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Zhang, Dewu; Ge, Hanlin; Xie, Dan; Chen, Ridao; Zou, Jian-hua; Tao, Xiaoyu; et al. (2016). Periconiasins A–C, New Cytotoxic Cytochalasans with an Unprecedented 9/6/5 Tricyclic Ring System from Endophytic Fungus Periconia sp.. ACS Publications. Collection. https://doi.org/10.1021/ol400458n

https://doi.org/10.1021/ol400458n

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