Pd(PPh3)4-PEG 400 Catalyzed Protocol for the Atom-Efficient Stille Cross-Coupling Reaction of Organotin with Aryl Bromides

Wang, Jin-Xian

Pd(PPh₃)₄-PEG 400 Catalyzed Protocol for the Atom-Efficient Stille Cross-Coupling Reaction of Organotin with Aryl Bromides

Posted on 2009-08-07 - 00:00

Aryl bromides (4 equiv) were coupled efficiently with organotin (1 equiv) in an atom-efficient way using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 (Pd(PPh₃)₄/PEG 400) catalytic system in the presence of sodium acetate (NaOAc) as base at 100 °C, providing excellent yields of the corresponding functionalized biaryls in short reaction times.

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Zhou, Wen-Jun; Wang, Ke-Hu; Wang, Jin-Xian (2016). Pd(PPh₃)₄-PEG 400 Catalyzed Protocol for the Atom-Efficient Stille Cross-Coupling Reaction of Organotin with Aryl Bromides. ACS Publications. Collection. https://doi.org/10.1021/jo9005206

https://doi.org/10.1021/jo9005206

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