Pd-Catalyzed Atroposelective C–H Allylation
and Alkenylation: Access to Enantioenriched Atropisomers Featuring
Pentatomic Heteroaromatics
Posted on 2019-08-23 - 20:16
The development of efficient and
unified synthetic methods to access
enantioenriched pentatomic biaryls is extremely challenging, due to
the relatively low rotational barriers of these five-membered atropisomeric
species, Described herein is a Pd-catalyzed asymmetric C–H
allylation and alkenylation to prepare such atropisomers. This protocol
is tolerant of various five-membered biaryls containing benzothiophenes
and benzofurans, providing pentatomic biaryls with good to excellent
enantioselectivities (up to 99% ee).
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Chen, Hao-Ming; Zhang, Shuo; Liao, Gang; Yao, Qi-Jun; Xu, Xue-Tao; Zhang, Kun; et al. (2019). Pd-Catalyzed Atroposelective C–H Allylation
and Alkenylation: Access to Enantioenriched Atropisomers Featuring
Pentatomic Heteroaromatics. ACS Publications. Collection. https://doi.org/10.1021/acs.organomet.9b00490
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AUTHORS (7)
HC
Hao-Ming Chen
SZ
Shuo Zhang
GL
Gang Liao
QY
Qi-Jun Yao
XX
Xue-Tao Xu
KZ
Kun Zhang
BS
Bing-Feng Shi