Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum

Posted on 15.09.2021 - 10:13
Four polyketide–amino acid derivatives, pardinumones A–D (14), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dichroism (ECD) and NMR with sorted training set (STS) protocol analysis. Compounds 14 exhibited antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with MIC values in the range of 6.25–50 μg/mL.

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Yang, Hui-Xiang; Ma, Jin-Tao; He, Juan; Li, Zheng-Hui; Huang, Rong; Feng, Tao; et al. (2021): Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum. ACS Publications. Collection. https://doi.org/10.1021/acsomega.1c04418
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