Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination
of Alkenyl Chlorides

Onomura, Osamu

Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides

Version 2 2019-08-15, 12:06

Version 1 2019-07-18, 12:09

Posted on 2019-08-15 - 12:06

The palladium-catalyzed deuterodechlorination of alkenyl chlorides has been developed, and a variety of deuterated alkenes were synthesized with precise control of the deuterium incorporation. This catalytic process tolerates heterocyclic moieties and frameworks derived from bioactive agents. In addition to the double incorporation of deuterium, the gram-scale synthesis of a deuterated iminostilbene unit including a core substructure of carbamazepine was achieved in a high yield with an excellent degree of deuteration.

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Kuriyama, Masami; Yano, Gemba; Kiba, Hirotoshi; Morimoto, Tetsuro; Yamamoto, Kosuke; Demizu, Yosuke; et al. (2019). Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides. ACS Publications. Collection. https://doi.org/10.1021/acs.oprd.9b00193

https://doi.org/10.1021/acs.oprd.9b00193

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