Oxygen-Generating Photo-Cross-Linkable Hydrogels Support
Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis
Version 3 2017-08-30, 13:51
Version 2 2017-06-22, 19:34
Version 1 2016-06-20, 14:48
Posted on 2017-08-30 - 13:51
Oxygen
is essential to cell survival and tissue function. Not surprisingly,
ischemia resulting from myocardial infarction induces cell death and
tissue necrosis. Attempts to regenerate myocardial tissue with cell
based therapies exacerbate the hypoxic stress by further increasing
the metabolic burden. In consequence, implanted tissue engineered
cardiac tissues suffer from hypoxia-induced cell death. Here, we report
on the generation of oxygen-generating hydrogels composed of calcium
peroxide (CPO) laden gelatin methacryloyl (GelMA). CPO-GelMA hydrogels
released significant amounts of oxygen for over a period of 5 days
under hypoxic conditions (1% O2). The released oxygen proved
sufficient to relieve the metabolic stress of cardiac side population
cells that were encapsulated within CPO-GelMA hydrogels. In particular,
incorporation of CPO in GelMA hydrogels strongly enhanced cell viability
as compared to GelMA-only hydrogels. Importantly, CPO-based oxygen
generation reduced cell death by limiting hypoxia-induced necrosis.
The current study demonstrates that CPO based oxygen-generating hydrogels
could be used to transiently provide oxygen to cardiac cells under
ischemic conditions. Therefore, oxygen generating materials such as
CPO-GelMA can improve cell-based therapies aimed at treatment or regeneration
of infarcted myocardial tissue.
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Alemdar, Neslihan; Leijten, Jeroen; Camci-Unal, Gulden; Hjortnaes, Jesper; Ribas, Joao; Paul, Arghya; et al. (2016). Oxygen-Generating Photo-Cross-Linkable Hydrogels Support
Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.6b00109
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AUTHORS (12)
NA
Neslihan Alemdar
JL
Jeroen Leijten
GC
Gulden Camci-Unal
JH
Jesper Hjortnaes
JR
Joao Ribas
AP
Arghya Paul
PM
Pooria Mostafalu
AG
Akhilesh K. Gaharwar
YQ
Yiling Qiu
SS
Sameer Sonkusale
RL
Ronglih Liao
AK
Ali Khademhosseini