One-Pot Three-Component Strategy for Functionalized 2‑Aminoimidazoles via Ring Opening of α‑Nitro Epoxides

Yu, Yongping

One-Pot Three-Component Strategy for Functionalized 2‑Aminoimidazoles via Ring Opening of α‑Nitro Epoxides

Posted on 2015-03-06 - 00:00

Functionalized 2-aminoimidazole derivatives have been synthesized via a three-component domino reaction of α-nitroepoxides and cyanamide with a series of amines under mild conditions without the need for any additives. This reaction represents a practical process for the facile conversion of α-nitroepoxides to 2-aminoimidazoles via ring opening of epoxides.

CITE THIS COLLECTION

Guo, Xiao; Chen, Wenteng; Chen, Binhui; Huang, Wei; Qi, Weixing; Zhang, Guolin; et al. (2016). One-Pot Three-Component Strategy for Functionalized 2‑Aminoimidazoles via Ring Opening of α‑Nitro Epoxides. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.5b00289

https://doi.org/10.1021/acs.orglett.5b00289

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