One- and Two-Photon
Uncaging of Carbon Monoxide (CO)
with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing
Platform to Test over Single and Combinatorial Approaches for the
Efficient Regression of Orthotopic Murine Melanoma In Vivo
Posted on 14.01.2022 - 21:13
Herein, we report three new metal-free, photochemically active single, dual, and combinatorial CORMs (photoCORMs) based on a carbazole-fused 1,3-dioxol-2-one moiety which released one equivalent of CO, two equivalent of CO, and a combination of one equivalent of each CO and anticancer drug upon one- and two-photon excitation, respectively. The photoCORMs exhibited good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells. Interestingly, the cytotoxicity assay on B16F10 cells indicated that the dual photoCORM has increased anticancer activity over the single and combinatorial photoCORMs upon irradiation. Our results also showed that CO could accelerate the effectiveness of the well-known anticancer drug (chlorambucil). Finally, the in vivo evaluation of the dual photoCORM on an established murine melanoma tumor (C57BL/6J mouse model) manifested a significant regression of tumor volume and led to significant improvement (>50%) in the overall survivability.
CITE THIS COLLECTION
Venkatesh, Yarra; Vangala, Venugopal; Mengji, Rakesh; Chaudhuri, Amrita; Bhattacharya, Sayantan; Datta, Prasanta Kumar; et al. (2022): One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma In Vivo. ACS Publications. Collection. https://doi.org/10.1021/acs.jmedchem.1c00750
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Prasanta Kumar Datta
N. D. Pradeep Singh
results also showedorthotopic murine melanomaknown anticancer drugincreased anticancer activitycolor change approachcancerous b16f10 cellsb16f10 cells indicated6j mouse modelco could acceleratetime monitoring abilityphotochemically active singlereleased one equivalentbased dual cotime monitoringone equivalentco uncagingvivo </tumor volumesignificant regressionreleasing platformphoton uncagingphoton excitationoverall survivabilityone moietyfused 1efficient regressiondual photocormcytotoxicity assaycombinatorial cormscombinatorial approacheschlorambucil ).carbon monoxide