One-Step Synthesis of Diaza Macrocycles by Rh(II)-Catalyzed [3 + 6 + 3 + 6] Condensations of Morpholines and
α‑Diazo-β-ketoesters
Posted on 2019-01-18 - 20:13
Selective formation
of oxonium ylides from morpholines and α-diazo-β-ketoesters
was achieved. This was applied to the high-concentration (0.5 M) dirhodium-catalyzed
(0.1 mol %) [3 + 6 + 3 + 6] synthesis of 18-membered ring diaza
macrocycles (46%–72%). Late-stage functionalization of these
derivatives is demonstrated. Mechanistic evidence for a novel (undesired)
diazo decomposition pathway is also reported.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Homberg, Alexandre; Poggiali, Daniele; Vishe, Mahesh; Besnard, Céline; Guénée, Laure; Lacour, Jérôme (2019). One-Step Synthesis of Diaza Macrocycles by Rh(II)-Catalyzed [3 + 6 + 3 + 6] Condensations of Morpholines and
α‑Diazo-β-ketoesters. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b03875
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (6)
AH
Alexandre Homberg
DP
Daniele Poggiali
MV
Mahesh Vishe
CB
Céline Besnard
LG
Laure Guénée
JL
Jérôme Lacour