One-Step
Precise Characterization of Drug Delivery
Systems by PULCON Magnetic Resonance Spectroscopy
Posted on 2024-05-16 - 03:43
Polymers are extensively used for the realization of
drug delivery
systems across multiple scales, from nanomedicines to microparticles
and macroscopic implantable devices, for their favorable biodegradation
profiles and tunable physicochemical features. The accurate quantification
of the polymer content is key to finely controlling drug loading and
release and ensuring reproducibility, yet it continues to be a major
challenge in the design and development of delivery systems. In this
study, we introduce a novel protocol based on the PULCON technique
to quantify, with a routine NMR spectroscopy analysis, the precise
concentration of polymers in various delivery systems. Specifically,
the PULCON protocol is applied to characterize the physicochemical
and pharmaceutical properties of nanoparticles, microparticles, and
implantable devices realized by combining three extensively used polymers,
namely, poly(lactic-co-glycolic acid) (PLGA), poly(vinyl
alcohol) (PVA), and poly(ethylene glycol) (PEG). Without using internal
calibration procedures, in a single step, the PULCON protocol precisely
quantifies the concentration of each polymer and the drug content.
This approach can be readily implemented on standard NMR spectrometers,
enabling accurate characterization of drug delivery systems and facilitating
their effective development.
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Pesce, C.; Goldoni, L.; Papa, V.; Palange, A. L.; Di Mascolo, D.; Caliceti, P.; et al. (2024). One-Step
Precise Characterization of Drug Delivery
Systems by PULCON Magnetic Resonance Spectroscopy. ACS Publications. Collection. https://doi.org/10.1021/acs.molpharmaceut.4c00076