Nucleophilic Aromatic
Substitution of 5‑Bromo-1,2,3-triazines
with Phenols

Li, Baosheng

Nucleophilic Aromatic Substitution of 5‑Bromo-1,2,3-triazines with Phenols

Posted on 2022-02-15 - 14:07

Nucleophilic aromatic substitution (S_NAr) reaction in classic textbook is a stepwise mechanism, and few examples of concerted reactions have been reported. Herein, we developed a concerted S_NAr reaction of 5-bromo-1,2,3-triazines with phenols in which the nonclassic mechanism of this reaction could be revealed by calculation. Furthermore, the resulting 5-aryloxy-1,2,3-triazines could be used as convenient precursors to access biologically important 3-aryloxy-pyridines in one-pot manner.

CITE THIS COLLECTION

Luo, Han; Li, Yumeng; Zhang, Yuan; Lu, Qixing; An, Qiaoyu; Xu, Mingchuan; et al. (2022). Nucleophilic Aromatic Substitution of 5‑Bromo-1,2,3-triazines with Phenols. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.1c02543

https://doi.org/10.1021/acs.joc.1c02543

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