Novel Salt Cocrystal
of Chrysin with Berberine: Preparation,
Characterization, and Oral Bioavailability
Posted on 2018-07-13 - 18:00
A novel salt cocrystal
of chrysin (ChrH) with berberine (BerbOH),
[Berb+–Chr–]-2ChrH (1), was prepared. Crystal structure analysis shows one chrysin lost
its proton in 7-hydroxyl group and turned into a chrysin anion. Two
neutral chrysin molecules interact simultaneously with chrysin anion
through charge-assisted strong hydrogen-bonding interactions between
phenolic anion and hydroxyl groups of chrysin to give rise to a 1:3
salt cocrystal based on berberine and chrysin. Density functional
theoretical calculations indicate that the 1:3 stoichiometry of berberine
and chrysin is more stable due to its largest interaction energies.
The bioavailability of chrysin in the form of cocrystal 1 in rats is about 1.7 times than that of pure chrysin.
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Sa, Rongjian; Zhang, Yanjie; Deng, Yanping; Huang, Yali; Zhang, Mei; Lou, Benyong (2018). Novel Salt Cocrystal
of Chrysin with Berberine: Preparation,
Characterization, and Oral Bioavailability. ACS Publications. Collection. https://doi.org/10.1021/acs.cgd.8b00696
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AUTHORS (6)
RS
Rongjian Sa
YZ
Yanjie Zhang
YD
Yanping Deng
YH
Yali Huang
MZ
Mei Zhang
BL
Benyong Lou