Nonswellable and Tough Supramolecular Hydrogel Based
on Strong Micelle Cross-Linkings
Posted on 2019-08-08 - 16:46
Because of the difference
in osmotic pressure, most tough hydrogels
swell under physiological conditions, which seriously weakens their
mechanical properties, limiting their applications in biomedicine.
Herein, a novel strategy based on strong and high-density micelle
cross-linkings is proposed to prepare nonswellable and tough hydrogel.
To realize a strong micelle cross-linker, the synergetic effect of
hydrophobic and quadruple hydrogen-bonding interactions is employed
by introducing an alkyl chain-protected ureido pyrimidinone moiety
into a segmented copolymer backbone. The length of the alkyl is the
key factor in determining the strength of the hydrophobic interaction,
which was carefully tailored to gain micelles with high strength and
suitable solubility. A supramolecular hydrogel was formed in situ
by simply linking micelle cross-linkers with poly(ethylene glycol)
chains. The strong and high-density micelle cross-linkings restrain
multiple effective chains outside the micelle from stretching during
swelling, and the deformability of micelle cross-linkings disperses
the local stress to maintain the network with high cross-linking density
upon loading. Therefore, the hydrogel exhibited an outstanding nonswelling
behavior under physiological conditions and excellent mechanical properties
with a compressive strength of 4 MPa. The rapid in situ gelation also
facilitated injection and cell encapsulation. Meanwhile, it also showed
good tissue adhesion, cytocompatibility, and suitable degradability.
This novel and facile strategy can offer new insights into the exploitation
of cross-linkings to prepare nonswellable hydrogels for biomedical
applications.
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Qin, Zezhao; Yu, Xiaofeng; Wu, Haiyang; Li, Jinge; Lv, Hongying; Yang, Xiaoniu (2019). Nonswellable and Tough Supramolecular Hydrogel Based
on Strong Micelle Cross-Linkings. ACS Publications. Collection. https://doi.org/10.1021/acs.biomac.9b00666