Nickel-Catalyzed Vinylation of Aryl Chlorides and Bromides with Vinyl ZnBr·MgBrCl

Yamakawa, Tetsu

Nickel-Catalyzed Vinylation of Aryl Chlorides and Bromides with Vinyl ZnBr·MgBrCl

Posted on 2009-05-01 - 00:00

The Ni-catalyzed cross-coupling of aryl halides and vinylzinc bromide for the synthesis of styrene derivatives was investigated. Of the catalysts surveyed, the combination of Ni(acac)₂ and Xantphos was found to be the most effective for this cross-coupling. This catalyst could be used in reactions with various aryl bromides and chlorides, including electron-rich aryl chlorides such as chloroanisoles.

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Yamamoto, Tetsuya; Yamakawa, Tetsu (2016). Nickel-Catalyzed Vinylation of Aryl Chlorides and Bromides with Vinyl ZnBr·MgBrCl. ACS Publications. Collection. https://doi.org/10.1021/jo900290t

https://doi.org/10.1021/jo900290t

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