Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition
Reaction
Posted on 2019-01-11 - 20:03
A nickel-catalyzed defluorination
of α-trifluoromethylated
allyl/propargyl carbonates using bis(pinacolato)diboron (B2pin2) as a reactant is described. The reaction proceeds
under relatively mild reaction conditions, providing conjugated gem-difluoroalkenes in moderate to good yields. Applications
of the resulting 1,1-difluoro-1,3-dienes by [4 + 2] cycloaddition
reactions with maleimide led to cyclic fluorinated products efficiently.
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Zhou, Minqi; Zhang, Jian; Zhang, Xing-Guo; Zhang, Xingang (2019). Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition
Reaction. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b03841
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AUTHORS (4)
MZ
Minqi Zhou
JZ
Jian Zhang
XZ
Xing-Guo Zhang
XZ
Xingang Zhang