Ni-Catalyzed Defluorination for the Synthesis of <i>gem</i>-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition Reaction

Published on 2019-01-11T20:03:31Z (GMT) by
A nickel-catalyzed defluorination of α-trifluoromethylated allyl/propargyl carbonates using bis­(pinacolato)­diboron (B<sub>2</sub>pin<sub>2</sub>) as a reactant is described. The reaction proceeds under relatively mild reaction conditions, providing conjugated <i>gem</i>-difluoroalkenes in moderate to good yields. Applications of the resulting 1,1-difluoro-1,3-dienes by [4 + 2] cycloaddition reactions with maleimide led to cyclic fluorinated products efficiently.

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Zhou, Minqi; Zhang, Jian; Zhang, Xing-Guo; Zhang, Xingang (2019): Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition

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