Near-Infrared-Triggered
Dynamic Surface Topography
for Sequential Modulation of Macrophage Phenotypes
Posted on 2019-11-08 - 22:30
Immune
response is critical to tissue repair. Designing biomaterials
with immunomodulatory functions has become a promising strategy to
facilitate tissue repair. Considering the key roles of macrophages
in tissue repair and the significance of the balance of M1 and M2,
smart biomaterials, which can harness macrophage phenotypes dynamically
to match the tissue healing process on demand, have attracted a lot
of attention to be set apart from the traditional anti-inflammatory
biomaterials. Here, we prepare a gold nanorod-contained shape memory
polycaprolactone film with dynamic surface topography, which has the
ability to be transformed from flat to microgrooved under near-infrared
(NIR) irradiation. Based on the close relationships between the morphologies
and the phenotypes of macrophages, the NIR-triggered surface transformation
induces the elongation of macrophages, and consequently the upregulated
expressions of arginase-1 and IL-10 in vitro, indicating the change
of macrophage phenotypes. The sequential modulation of macrophage
phenotypes by dynamic surface topography is further confirmed in an
in vivo implantation test. The healing-matched modulation of macrophage
phenotypes by dynamic surface topography without the stimuli of cytokines
offers an effective and noninvasive strategy to manipulate tissue
regenerative immune reactions to achieve optimized healing outcomes.
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3 Biotech
3D Printing in Medicine
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AAPG Bulletin
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Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
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Zheng, Xiaowen; Xin, Liaobing; Luo, Yilun; Yang, Huang; Ye, Xingyao; Mao, Zhengwei; et al. (2019). Near-Infrared-Triggered
Dynamic Surface Topography
for Sequential Modulation of Macrophage Phenotypes. ACS Publications. Collection. https://doi.org/10.1021/acsami.9b14808
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AUTHORS (9)
XZ
Xiaowen Zheng
LX
Liaobing Xin
YL
Yilun Luo
HY
Huang Yang
XY
Xingyao Ye
ZM
Zhengwei Mao
SZ
Songying Zhang
LM
Lie Ma
CG
Changyou Gao
KEYWORDS
tissue healing processNear-Infrared-Triggered Dynamic Surface Topographygold nanorod-contained shape memory polycaprolactone filmoptimized healing outcomesvivo implantation testbiomaterialmacrophage phenotypestissue repairMacrophage Phenotypes Immune responseNIR-triggered surface transformationsurface topographyIL