N‑Halamine
Derivatized Nanoparticles with Selective
Cyanocidal Activity: Potential for Targeted Elimination of Harmful
Cyanobacterial Blooms
Posted on 2019-07-21 - 12:29
Harmful cyanobacterial blooms (HCBs)
are becoming a major challenge
for the management of both natural and man-made freshwater lakes and
reservoirs. Phytoplankton communities are an essential component of
aquatic ecosystems, providing the basis for natural food webs as well
as important environmental services. HCBs, driven by a combination
of environmental pollution and rising global temperatures, destabilize
phytoplankton communities with major impacts on aquatic ecology and
trophic interactions. Application of currently available algaecides
generally results in unselective elimination of phytoplankton species,
disrupting water ecology and environmental services provided by beneficial
algae. There is thus a need for selective cyanocidal compounds that
can eliminate cyanobacteria while preserving algal members of the
phytoplankton community. Here, we demonstrate the efficacy of N-halamine
derivatized nanoparticles (Cl NPs) in selectively eliminating cyanobacteria,
including the universal bloom-forming species Microcystis
aeruginosa, while having minimal effect on co-occurring
algal species. We further support these results with the use a simple
microfluidic platform in combination with advanced live-imaging microscopy
to study the effects of Cl NPs on both laboratory cultures and natural
populations of cyanobacteria and algae at single cell resolutions.
We note that the Cl NPs used in this work were made of polymethacrylamide,
a nonbiodegradable polymer that may be unsuitable for use as a cyanocide
in open aquatic environments. Nevertheless, the demonstrated selective
action of these Cl NPs suggests a potential for developing alternative,
biodegradable carriers with similar properties as future cyanocidal
agents that will enable selective elimination of HCBs.
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Sadhasivam, Giji; Gelber, Chen; Zakin, Varda; Margel, Shlomo; Shapiro, Orr H. (2019). N‑Halamine
Derivatized Nanoparticles with Selective
Cyanocidal Activity: Potential for Targeted Elimination of Harmful
Cyanobacterial Blooms. ACS Publications. Collection. https://doi.org/10.1021/acs.est.9b01368