Mycoleptones
A–C and Polyketides from the Endophyte Mycoleptodiscus
indicus
Posted on 2014-01-24 - 00:00
Three new azaphilones with an unusual
methylene bridge, named mycoleptones
A, B, and C (2, 4, and 5),
were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides,
austdiol (1), eugenitin (3), 6-methoxyeugenin
(6), and 9-hydroxyeugenin (7), were also
isolated. The structural characterization of compounds was carried
out by nuclear magnetic resonance spectroscopy, high-resolution mass
spectrometry, electronic circular dichroism spectroscopy, time-dependent
density functional theory calculations, and X-ray crystallography.
Compounds 1–9 were weakly active
when tested in antileishmanial and cytotoxicity assays.
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Andrioli, Willian
J.; Conti, Raphael; Araújo, Magali J.; Zanasi, Riccardo; Cavalcanti, Bruno C.; Manfrim, Viviane; et al. (2016). Mycoleptones
A–C and Polyketides from the Endophyte Mycoleptodiscus
indicus. ACS Publications. Collection. https://doi.org/10.1021/np4006822