Model-Based Scale-Up Predictions: From Micro- to Millireactors
Using Inline Fourier Transform Infrared Spectroscopy
Posted on 2019-08-19 - 21:45
Scale-up
predictions from a continuous flow micro- (lab) to milliscale
(pilot or production) are important but not trivial. To overcome the
necessity of time-consuming trials on the pilot or production scale,
this work presents a model-based approach that builds on prior lab
experiments. However, it also improves the understanding of the involved
chemical process. A complete process development for a highly exothermic
organometallic reaction is conducted. Kinetic studies on a lab scale,
using inline FT-IR measurements, constitute the basis for a systematic
scale-up approach. Subsequently, the scale-up from microreactors (inner
diameter of 0.5 mm) to milliscale pilot reactors (inner diameter of
2 mm) through increasing the channel diameter and flow rates is investigated.
Model-based scale-up predictions are presented, including heat and
mass balances.
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Fath, Verena; Szmais, Stefanie; Lau, Philipp; Kockmann, Norbert; Röder, Thorsten (2019). Model-Based Scale-Up Predictions: From Micro- to Millireactors
Using Inline Fourier Transform Infrared Spectroscopy. ACS Publications. Collection. https://doi.org/10.1021/acs.oprd.9b00265
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AUTHORS (5)
VF
Verena Fath
SS
Stefanie Szmais
PL
Philipp Lau
NK
Norbert Kockmann
TR
Thorsten Röder
KEYWORDS
Spectroscopy Scale-up predictionsKinetic studiesmodel-based approachproduction scalemass balancesinline FT-IR measurementschemical process0.5 mmprocess developmentscale-up approachModel-based scale-up predictions2 mmlab experimentsInline Fourier Transformmilliscale pilot reactorslab scaleorganometallic reactionflow ratesModel-Based Scale-Up Predictionschannel diameter