Metabolic Profiling of Different Parts of Acer truncatum from the Mongolian Plateau Using UPLC-QTOF-MS
with Comparative Bioactivity Assays
Posted on 2019-01-23 - 22:14
Acer truncatum is an important ornamental, edible,
and medicinal plant resource in China. Previous phytochemical research
has focused on the leaf (AL) due to its long history as a tea for
health. Other parts such as the branch (ABr), bark (ABa), fruit (AF),
and root (AR) have drawn little attention regarding their metabolites
and bioactivities. The strategy of an in-house chemical library combined
with Progenesis QI informatics platform was applied to characterize
the metabolites. A total of 98 compounds were characterized or tentatively
identified, including 63 compounds reported from this species for
the first time. Principal component analysis showed the close clustering
of ABr, ABa, and AR, indicating that they share similar chemical components,
while AL and AF clustered more distantly. By multiple orthogonal partial
least-squares discriminant analyses (OPLS-DA), 52 compounds were identified
as potential marker compounds differentiating these different plant
parts. The variable influence on projection score from OPLS-DA revealed
that catechin, procyanidins B2 or B3, and procyanidins C1 or C2 are
the significant metabolites in ABa extracts, which likely contribute
to its antioxidant and cytotoxic activities.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Gu, Ronghui; Rybalov, Levi; Negrin, Adam; Morcol, Taylan; Long, Weiwen; Myers, Amanda K.; et al. (2019). Metabolic Profiling of Different Parts of Acer truncatum from the Mongolian Plateau Using UPLC-QTOF-MS
with Comparative Bioactivity Assays. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.8b04035
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
AUTHORS (10)
RG
Ronghui Gu
LR
Levi Rybalov
AN
Adam Negrin
TM
Taylan Morcol
WL
Weiwen Long
AM
Amanda K. Myers
GI
Giorgis Isaac
JY
Jimmy Yuk
EK
Edward J. Kennelly
CL
Chunlin Long
KEYWORDS
Comparative Bioactivity Assays Acer truncatum63 compoundsmetaboliteABa extractsplant resourceDifferent Partsprocyanidins B 2marker compoundsPrincipal component analysischemical librarychemical componentsAcer truncatumPrevious phytochemical researchcytotoxic activitiesleast-squares discriminant analysesprocyanidins C 1plant partsOPLS-DAC 2Other partsprojection scoreMetabolic Profiling98 compoundsAFALARProgenesis QI informatics platformMongolian PlateauUPLC-QTOF-MSABr