Liquid-Infused
Structured Titanium Surfaces: Antiadhesive Mechanism to Repel Streptococcus oralis Biofilms
Version 2 2019-06-20, 14:37
Version 1 2019-06-19, 21:29
Posted on 2019-06-20 - 14:37
To combat implant-associated
infections, there is a need for novel materials which effectively
inhibit bacterial biofilm formation. In the present study, the antiadhesive
properties of titanium surface functionalization based on the “slippery
liquid-infused porous surfaces” (SLIPS) principle were demonstrated
and the underlying mechanism was analyzed. The immobilized liquid
layer was stable over 13 days of continuous flow in an oral flow chamber
system. With increasing flow rates, the surface exhibited a significant
reduction in attached biofilm of both the oral initial colonizer Streptococcus oralis and an oral multispecies biofilm composed
of S. oralis, Actinomyces naeslundii, Veillonella dispar, and Porphyromonas
gingivalis. Using single cell force spectroscopy, reduced S. oralis adhesion forces on the lubricant layer could be
measured. Gene expression patterns in biofilms on SLIPS, on control
surfaces, and expression patterns of planktonic cultures were also
compared. For this purpose, the genome of S. oralis strain ATCC 9811 was sequenced using PacBio Sequel technology. Even
though biofilm cells showed clear changes in gene expression compared
to planktonic cells, no differences could be detected between bacteria
on SLIPS and on control surfaces. Therefore, it can be concluded that
the ability of liquid-infused titanium to repel S. oralis biofilms is mainly due to weakened bacterial adhesion to the underlying
liquid interface.
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Doll, Katharina; Yang, Ines; Fadeeva, Elena; Kommerein, Nadine; Szafrański, Szymon P.; Bei der Wieden, Gesa; et al. (2019). Liquid-Infused
Structured Titanium Surfaces: Antiadhesive Mechanism to Repel Streptococcus oralis Biofilms. ACS Publications. Collection. https://doi.org/10.1021/acsami.9b06817
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AUTHORS (11)
KD
Katharina Doll
IY
Ines Yang
EF
Elena Fadeeva
NK
Nadine Kommerein
SS
Szymon P. Szafrański
GB
Gesa Bei der Wieden
AG
Andreas Greuling
AW
Andreas Winkel
BC
Boris N. Chichkov
NS
Nico S. Stumpp
MS
Meike Stiesch
KEYWORDS
combat implant-associated infectionsRepel Streptococcus oralis Biofilmscontrol surfacestitanium surface functionalizationPacBio Sequel technologycolonizer Streptococcus oralisLiquid-Infused Structured Titanium Surfacesoralis adhesion forcesgene expression patternscell force spectroscopybiofilmoralis strain ATCC 9811flow chamber system