Liposomes in Polymersomes: Multicompartment System
with Temperature-Triggered Release
Posted on 2017-06-27 - 00:00
Multicompartmentalization
is a key feature of eukaryotic cells,
allowing separation and protection of species within the membrane
walls. During the last years, several methods have been reported to
afford synthetic multicompartment lipidic or polymeric vesicles that
mimic biological cells and that allow cascade chemical or enzymatic
reactions within their lumen. We hereby report on the preparation
and study of liposomes in polymersomes (LiPs) systems. We discuss
on the loading and coloading of lipidic nanovesicles made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine (diC15-PC), or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) inside the lumen of giant
poly(butadiene)-b-poly(ethylene oxide) (PBut-b-PEO) polymersomes. These LiPs systems were characterized
by confocal microscopy and UV–visible spectroscopy. We further
demonstrate that we can achieve controlled sequential release of dyes
from diC15-PC and DPPC liposomes at defined temperatures inside the
giant PBut-b-PEO polymersomes. This controlled release
could be used as a means to initiate cascade reactions on demand in
confined microreactors.
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Peyret, Ariane; Ibarboure, Emmanuel; Pippa, Natassa; Lecommandoux, Sebastien (2017). Liposomes in Polymersomes: Multicompartment System
with Temperature-Triggered Release. ACS Publications. Collection. https://doi.org/10.1021/acs.langmuir.7b00655