Lewis Acid-Catalyzed
Diastereoselective Synthesis
of Multisubstituted N‑Acylaziridine-2-carboxamides
from 2H‑Azirines via Joullié–Ugi
Three-Component Reaction

Kanizsai, Iván

Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N‑Acylaziridine-2-carboxamides from 2H‑Azirines via Joullié–Ugi Three-Component Reaction

Posted on 2018-03-02 - 00:00

A ZnCl₂-catalyzed diastereoselective Joullié–Ugi three-component reaction from 2H-azirines, isocyanides, and carboxylic acids was established. The protocol allows the preparation of highly and diversely functionalized N-acylaziridine-2-carboxamide derivatives in up to 82% isolated yields. Moreover, the applicability of N-acylaziridines is demonstrated through a variety of transformations.

CITE THIS COLLECTION

Angyal, Anikó; Demjén, András; Wéber, Edit; Kovács, Anita K.; Wölfling, János; Puskás, László G.; et al. (2018). Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N‑Acylaziridine-2-carboxamides from 2H‑Azirines via Joullié–Ugi Three-Component Reaction. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.7b03189

https://doi.org/10.1021/acs.joc.7b03189

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