Investigation of
Osteomyelitis Inducing Methicillin-Resistant Staphylococcus
aureus Inhibition Effect by Strontium-Substituted
Borate Bioactive Glasses
Posted on 2024-05-16 - 03:44
Borate glass transforms into hydroxycarbonate apatite
more rapidly
than silicate glass. This research aims to evaluate strontium’s
structural and biological effects on borate bioactive glass (BBG)
and the influence of strontium concentrations (0%, 5%, 10%, and 15%
Sr) prepared via the sol–gel method. The study reveals significant
findings related to the physicochemical properties of the glass. Immersion
of the glass powders in a simulated body fluid (SBF) led to the development
of a hydroxyapatite (HAP) layer on the glass surfaces. This transformation
was verified through X-ray diffraction (XRD), scanning electron microscopy
(SEM), and Fourier transform infrared (FTIR) analyses. In particular,
5% strontium exhibited gradual degradation, resulting in particle
sizes below 100 nm. The BBG-15%Sr demonstrates heightened pathogenic
activity as it shows a significant inhibition zone of 14 mm at 250
μg/mL, surpassing other substituted BBGs. It effectively combats
Gram-positive bacteria, completely inhibiting MRSA growth at 50 μg/mL.
This underscores its robust biofilm disruption capabilities, eradicating
biofilms, even at minimal concentrations after prolonged exposure. C. elegans when subjected to BBG-15%Sr shows less ROS production
when compared with the others. Moreover, the results suggest that
the modified glass could be a potential material for the treatment
of osteomyelitis-affected bone repair.
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Mohan, Anne Seles; Ravindran, Deepthi Ramya; Marudhamuthu, Murugan; Rajan, Mariappan (2024). Investigation of
Osteomyelitis Inducing Methicillin-Resistant Staphylococcus
aureus Inhibition Effect by Strontium-Substituted
Borate Bioactive Glasses. ACS Publications. Collection. https://doi.org/10.1021/acsabm.4c00219