Inner and Outer Surface Functionalizations of Ultrasmall
Fluorescent Silica Nanorings As Shown by High-Performance Liquid Chromatography
Posted on 2019-07-16 - 14:11
In
the past two decades, ultrasmall fluorescent nanomaterials have
garnered significant interest in the fields of bioimaging and nanomedicine.
More recently, attention has shifted from purely spherical nanoparticles
to objects with a variety of different shapes, such as high-aspect-ratio,
hollow, and star-shaped nanomaterials. We have recently reported the
synthesis and characterization of ultrasmall silica nanoparticles
with complex shapes, including silica nanocages, silica nanorings,
and single-pore silica nanoparticles. Here, we focus on fluorescent
silica nanorings that are of particular interest for theranostic applications
in nanomedicine. We present in-depth studies of the synthesis and
orthogonal surface functionalization, successfully distinguishing
the inside and outside of the silica nanorings, utilizing a combination
of spectroscopic and analytical techniques including fluorescence
correlation spectroscopy and reversed-phase high-performance liquid
chromatography. Results suggest that despite the small silica ring
diameter of around 10 nm and below, it is possible to effectively
“hide” hydrophobic moieties on the inside of the rings
but that their number must be carefully engineered. We expect the
chemistry and methods developed here to be of interest to a range
of differently shaped porous nanoparticles within the ultrasmall-size
regime.
CITE THIS COLLECTION
DataCiteDataCite
3 Biotech3 Biotech
3D Printing in Medicine3D Printing in Medicine
3D Research3D Research
3D-Printed Materials and Systems3D-Printed Materials and Systems
4OR4OR
AAPG BulletinAAPG Bulletin
AAPS OpenAAPS Open
AAPS PharmSciTechAAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität HamburgAbhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)ABI Technik (German)
Academic MedicineAcademic Medicine
Academic PediatricsAcademic Pediatrics
Academic PsychiatryAcademic Psychiatry
Academic QuestionsAcademic Questions
Academy of Management DiscoveriesAcademy of Management Discoveries
Academy of Management JournalAcademy of Management Journal
Academy of Management Learning and EducationAcademy of Management Learning and Education
Academy of Management PerspectivesAcademy of Management Perspectives
Academy of Management ProceedingsAcademy of Management Proceedings
Academy of Management ReviewAcademy of Management Review
Turker, Melik
Z.; Gardinier, Thomas C.; Hinckley, Joshua A.; Contreras, Cintia B.; Woodruff, Fem; Ma, Kai; et al. (2019). Inner and Outer Surface Functionalizations of Ultrasmall
Fluorescent Silica Nanorings As Shown by High-Performance Liquid Chromatography. ACS Publications. Collection. https://doi.org/10.1021/acs.chemmater.9b01236