Impact of Multivalence and Self-Assembly in the Design
of Polymeric Antimicrobial Peptide Mimics
Posted on 2020-06-25 - 12:42
Antimicrobial resistance is an increasingly serious challenge for
public health and could result in dramatic negative consequences for
the health care sector during the next decades. To solve this problem,
antibacterial materials that are unsusceptible toward the development
of bacterial resistance are a promising branch of research. In this
work, a new type of polymeric antimicrobial peptide mimic featuring
a bottlebrush architecture is developed, using a combination of reversible
addition–fragmentation chain transfer (RAFT) polymerization
and ring-opening metathesis polymerization (ROMP). This approach enables
multivalent presentation of antimicrobial subunits resulting in improved
bioactivity and an increased hemocompatibility, boosting the selectivity
of these materials for bacterial cells. Direct probing of membrane
integrity of treated bacteria revealed highly potent membrane disruption
caused by bottlebrush copolymers. Multivalent bottlebrush copolymers
clearly outperformed their linear equivalents regarding bioactivity
and selectivity. The effect of segmentation of cationic and hydrophobic
subunits within bottle brushes was probed using heterograft copolymers.
These materials were found to self-assemble under physiological conditions,
which reduced their antibacterial activity, highlighting the importance
of precise structural control for such applications. To the best of
our knowledge, this is the first example to demonstrate the positive
impact of multivalence, generated by a bottlebrush topology in polymeric
antimicrobial peptide mimics, making these polymers a highly promising
material platform for the design of new bactericidal systems.
CITE THIS COLLECTION
DataCiteDataCite
3 Biotech3 Biotech
3D Printing in Medicine3D Printing in Medicine
3D Research3D Research
3D-Printed Materials and Systems3D-Printed Materials and Systems
4OR4OR
AAPG BulletinAAPG Bulletin
AAPS OpenAAPS Open
AAPS PharmSciTechAAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität HamburgAbhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)ABI Technik (German)
Academic MedicineAcademic Medicine
Academic PediatricsAcademic Pediatrics
Academic PsychiatryAcademic Psychiatry
Academic QuestionsAcademic Questions
Academy of Management DiscoveriesAcademy of Management Discoveries
Academy of Management JournalAcademy of Management Journal
Academy of Management Learning and EducationAcademy of Management Learning and Education
Academy of Management PerspectivesAcademy of Management Perspectives
Academy of Management ProceedingsAcademy of Management Proceedings
Academy of Management ReviewAcademy of Management Review
Laroque, Sophie; Reifarth, Martin; Sperling, Marcel; Kersting, Sebastian; Klöpzig, Stefanie; Budach, Patrick; et al. (2020). Impact of Multivalence and Self-Assembly in the Design
of Polymeric Antimicrobial Peptide Mimics. ACS Publications. Collection. https://doi.org/10.1021/acsami.0c05944