High-Throughput Detection of Multiple Contaminants Based on Portable Photoelectrochromic Sensor Chip

Posted on 14.10.2021 - 03:43
With the increasing concerns about the environment and food safety, it is necessary to develop portable, low-cost, and high-throughput biosensors for the simultaneous detection of multiple contaminates. However, traditional photoelectrochemical (PEC) biosensors lack the ability of multiplexed assays due to the inherent mechanism limitation. Also, specialized instruments are necessary for most PEC biosensors. In this work, a portable high-throughput sensor chip has been successfully developed. By introducing electrochromic materials, the detection is based on color change instead of electric signals, which reduces the limitation of instruments. This designed sensor chip is composed of three parallel sensing channels fabricated by laser etching. Each channel is modified with TiO2/3D-g-C3N4 composites with excellent PEC activity and electrochromic material Prussian blue (PB). Under light illumination, photoinduced electrons generated by TiO2/3D-g-C3N4 are injected into PB, and blue PB is reduced to colorless Prussian white. Three organic contaminates, ochratoxin A, lincomycin, and edifenphos, can be simultaneously detected because the binding of these molecules with aptamers affects the electron transfer and the corresponding color changes. This portable and high-throughput sensor chip provides a convenient choice for multiplexed assays with good sensitivity and accuracy.

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Hao, Nan; Zuo, Yanli; Dai, Zhen; Xiong, Meng; Wei, Jie; Qian, Jing; et al. (2021): High-Throughput Detection of Multiple Contaminants Based on Portable Photoelectrochromic Sensor Chip. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.1c03868
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