Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine
with a Layer-by-Layer Supramolecular Architecture

Villalonga, Reynaldo

Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture

Posted on 2019-08-02 - 13:34

Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of β-cyclodextrin-coated gold nanoparticles as capping element of benzimidazole functionalized mesoporous silica nanoparticles, and a second control layer based on an adatamantane-modified glucose oxidase derivative. The nanomachine was selectively fuelled by glucose and successfully employed for the autonomous release of doxorubicin in HeLa cancer cells.

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Jimenez-Falcao, Sandra; de Luis, Beatriz; García-Fernández, Alba; Llopis-Lorente, Antoni; Diez, Paula; Sánchez, Alfredo; et al. (2019). Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture. ACS Publications. Collection. https://doi.org/10.1021/acsabm.9b00338

https://doi.org/10.1021/acsabm.9b00338

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