Futunamine, a Pyrrole–Imidazole Alkaloid from
the Sponge Stylissa aff. carteri Collected off the Futuna Islands

Thomas, Olivier P.

Futunamine, a Pyrrole–Imidazole Alkaloid from the Sponge Stylissa aff. carteri Collected off the Futuna Islands

Posted on 2020-07-06 - 18:35

The chemical investigation of the sponge Stylissa aff. carteri collected around Futuna Islands in the Pacific Ocean led to the isolation of three new dimeric pyrrole 2-aminoimidazole alkaloids (PIAs). Futunamine (1) features an unprecedented pyrrolo[1,2-c]imidazole core, while two other new dimeric PIAs were identified as analogues of palau’amine. Together with other known PIAs isolated from this species, they were shown to exhibit anti-inflammatory and neuroprotective activities.

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Miguel-Gordo, Maria; Gegunde, Sandra; Jennings, Laurence K.; Genta-Jouve, Grégory; Calabro, Kevin; Alfonso, Amparo; et al. (2020). Futunamine, a Pyrrole–Imidazole Alkaloid from the Sponge Stylissa aff. carteri Collected off the Futuna Islands. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.0c00223

https://doi.org/10.1021/acs.jnatprod.0c00223

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