Four Phosphates at One Blow: Access to Pentaphosphorylated
Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis

Jessen, Henning J.

Four Phosphates at One Blow: Access to Pentaphosphorylated Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis

Posted on 2020-06-22 - 15:13

The complex phosphorylation pattern of natural and modified pentaphosphorylated magic spot nucleotides is generated in a highly efficient way. A cyclic pyrophosphoryl phosphoramidite (cPyPA) reagent is used to introduce four phosphates on nucleosides regioselectively in a one-flask key transformation. The obtained magic spot nucleotides are used to develop a capillary electrophoresis UV detection method, enabling nucleotide assignment in complex bacterial extracts.

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Haas, Thomas M.; Qiu, Danye; Häner, Markus; Angebauer, Larissa; Ripp, Alexander; Singh, Jyoti; et al. (2020). Four Phosphates at One Blow: Access to Pentaphosphorylated Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.0c00841

https://doi.org/10.1021/acs.joc.0c00841

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