Formation of the C Ring in the
Lanosterol Biosynthesis from Squalene

Hess, B. Andes

Formation of the C Ring in the Lanosterol Biosynthesis from Squalene

Posted on 2003-01-03 - 00:00

Ab initio calculations were performed on a cyclohexane derivative to elucidate the mechanism of the formation of the five-membered C ring in the biosynthesis of lanosterol from squalene. A conformational analysis of the side chain containing the double bond indicated that the conformer that should give rise to the cyclized C ring is not a minimum on the potential surface. Consequently, it is suggested that it is very likely that C-ring formation occurs in concert with formation of the A and B rings.

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Hess, B. Andes (2016). Formation of the C Ring in the Lanosterol Biosynthesis from Squalene. ACS Publications. Collection. https://doi.org/10.1021/ol027449c

https://doi.org/10.1021/ol027449c

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