Follow the Silyl Cation: Insights into the Vorbrüggen
Reaction
Posted on 2019-08-21 - 18:15
To succeed in the
development of a mechanistic model for the Vorbrüggen
reaction of thymine with an advanced furanose intermediate, a range
of spectroscopic techniques were applied and found essential to understanding
kinetically relevant, yet nonisolable, silylated reaction intermediates.
Understanding of the dynamic nature of the interaction of trimethylsilyl
trifluoromethanesulfonate with these functionally dense substrates
allowed for the accurate prediction and straightforward explanation
of the relationship between process parameters and the levels of key
impurities.
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Beutner, Gregory L.; Bultman, Michael S.; Cohen, Benjamin M.; Fan, Junying; Marshall, Jonathan; Sfouggatakis, Chris (2019). Follow the Silyl Cation: Insights into the Vorbrüggen
Reaction. ACS Publications. Collection. https://doi.org/10.1021/acs.oprd.9b00304
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AUTHORS (6)
GB
Gregory L. Beutner
MB
Michael S. Bultman
BC
Benjamin M. Cohen
JF
Junying Fan
JM
Jonathan Marshall
CS
Chris Sfouggatakis