Folate-Modified
Photoelectric Responsive Polymer Microarray as Bionic Artificial Retina
to Restore Visual Function
Posted on 2020-06-12 - 18:03
A high-optical-resolution
artificial retina system that accurately communicates with the optic
nerve is the main challenge in the modern biological science and bionic
field. Here, we developed a bionic artificial retina possessing phototransduction
“cells” with measurements even smaller than that of
the neural cells. Using the technique of micrometer processing, we
constructed a pyramid-shape periodic microarray of a photoreceptor.
Each “sensing cell” took advantage of polythiophene
derivative/fullerene derivative (PCBM) as a photoelectric converter.
Because folic acid played an essential role in eye growth, we particularly
modified the polythiophene derivatives with folic acid tags. Therefore,
the artificial retina could enlarge the contact area and even recognize
the nerve cells to improve the consequence of nerve stimulation. We
implanted the artificial retina into blinded rats’ eyes. Electrophysiological
analysis revealed its recovery of photosensitive function 3 months
after surgery. Our work provides an innovative idea for fabricating
a high-resolution bionic artificial retina system. It shows great
potential in artificial intelligence and biomedicine.
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