Fluorogenic Phospholipid Substrate to
Detect Lysophospholipase D/Autotaxin
Activity

Prestwich, Glenn D.

Fluorogenic Phospholipid Substrate to Detect Lysophospholipase D/Autotaxin Activity

Posted on 2006-05-11 - 00:00

Lysophospholipase D (lysoPLD), also known as autotaxin (ATX), is an important source of the potent mitogen lysophosphatidic acid (LPA). Two fluorogenic substrate analogues for lysoPLD were synthesized in nine steps from (S)-PMB-glycerol. The substrates (FS-2 and FS-3) show significant increases in fluorescence when treated with recombinant ATX and have potential applications in screening for this emerging drug target.

CITE THIS COLLECTION

Ferguson, Colin G.; Bigman, Cleve S.; Richardson, Robyn D.; A. van Meeteren, Laurens; Moolenaar, Wouter H.; Prestwich, Glenn D. (2016). Fluorogenic Phospholipid Substrate to Detect Lysophospholipase D/Autotaxin Activity. ACS Publications. Collection. https://doi.org/10.1021/ol060414i

https://doi.org/10.1021/ol060414i

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