Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic
Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus
flavipes 164013

Lin, Hou-Wen

Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013

Posted on 2020-02-14 - 15:14

Three unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides A–C (1–3), were isolated from a strain of marine sponge symbiotic fungus Aspergillus flavipes 164013. Their structures were determined by spectroscopic data analysis, and absolute configurations were assigned by single-crystal X-ray diffraction with ECD spectral analysis. Flavipesides A–C showed potent pancreatic lipase (PL) inhibitory activity with IC₅₀ values of 0.07–0.23 μM.

CITE THIS COLLECTION

DataCite

3 Biotech

3D Printing in Medicine

3D Research

3D-Printed Materials and Systems

4OR

AAPG Bulletin

AAPS Open

AAPS PharmSciTech

Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg

ABI Technik (German)

Academic Medicine

Academic Pediatrics

Academic Psychiatry

Academic Questions

Academy of Management Discoveries

Academy of Management Journal

Academy of Management Learning and Education

Academy of Management Perspectives

Academy of Management Proceedings

Academy of Management Review

Jiao, Wei-Hua; Xu, Qi-Hang; Ge, Guang-Bo; Shang, Ru-Yi; Zhu, Hong-Rui; Liu, Hong-Yan; et al. (2020). Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c00150

https://doi.org/10.1021/acs.orglett.0c00150

or

Select your citation style and then place your mouse over the citation text to select it.