Facile Synthesis of Uniform Virus-like Mesoporous
Silica Nanoparticles for Enhanced Cellular Internalization
Version 2 2017-08-23, 04:16
Version 1 2017-07-26, 12:06
Posted on 2017-08-23 - 04:16
The
low-efficiency cellular uptake property of current nanoparticles
greatly restricts their application in the biomedical field. Herein,
we demonstrate that novel virus-like mesoporous silica nanoparticles
can easily be synthesized, showing greatly superior cellular uptake
property. The unique virus-like mesoporous silica nanoparticles with
a spiky tubular rough surface have been successfully synthesized
via a novel single-micelle epitaxial growth approach in a low-concentration-surfactant
oil/water biphase system. The virus-like nanoparticles’ rough
surface morphology results mainly from the mesoporous silica nanotubes
spontaneously grown via an epitaxial growth process. The obtained
nanoparticles show uniform particle size and excellent monodispersity.
The structural parameters of the nanoparticles can be well tuned with
controllable core diameter (∼60–160 nm), tubular length
(∼6–70 nm), and outer diameter (∼6–10
nm). Thanks to the biomimetic morphology, the virus-like nanoparticles
show greatly superior cellular uptake property (invading living cells
in large quantities within few minutes, <5 min), unique internalization
pathways, and extended blood circulation duration (t1/2 = 2.16 h), which is much longer than that of conventional
mesoporous silica nanoparticles (0.45 h). Furthermore, our epitaxial
growth strategy can be applied to fabricate various virus-like mesoporous
core–shell structures, paving the way toward designed synthesis
of virus-like nanocomposites for biomedicine applications.
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Wang, Wenxing; Wang, Peiyuan; Tang, Xueting; Elzatahry, Ahmed A.; Wang, Shuwen; Al-Dahyan, Daifallah; et al. (2017). Facile Synthesis of Uniform Virus-like Mesoporous
Silica Nanoparticles for Enhanced Cellular Internalization. ACS Publications. Collection. https://doi.org/10.1021/acscentsci.7b00257
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AUTHORS (14)
WW
Wenxing Wang
PW
Peiyuan Wang
XT
Xueting Tang
AE
Ahmed A. Elzatahry
SW
Shuwen Wang
DA
Daifallah Al-Dahyan
MZ
Mengyao Zhao
CY
Chi Yao
CH
Chin-Te Hung
XZ
Xiaohang Zhu
TZ
Tiancong Zhao
XL
Xiaomin Li
FZ
Fan Zhang
DZ
Dongyuan Zhao
KEYWORDS
surface morphology resultsnovel virus-like mesoporous silica nanoparticlesnanoparticles show uniform particle sizeblood circulation durationnovel single-micelle epitaxial growth approachUniform Virus-like Mesoporous Silica Nanoparticlesuptake propertyvirus-like nanoparticles shownmepitaxial growth strategyvirus-like mesoporous silica nanoparticlesEnhanced Cellular Internalizationepitaxial growth processmesoporous silica nanotubes