Enantioselective Hydroformylation of 1‑Alkenes
with Commercial Ph-BPE Ligand

Morken, James P.

Enantioselective Hydroformylation of 1‑Alkenes with Commercial Ph-BPE Ligand

Posted on 2015-07-02 - 00:00

A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates α-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1).

CITE THIS COLLECTION

Yu, Zhiyong; Eno, Meredith S.; Annis, Alexandra H.; Morken, James P. (2016). Enantioselective Hydroformylation of 1‑Alkenes with Commercial Ph-BPE Ligand. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.5b01421

https://doi.org/10.1021/acs.orglett.5b01421

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