Eliminating
Heat Injury of Zeolite in Hemostasis via
Thermal Conductivity of Graphene Sponge
Posted on 2019-06-26 - 21:30
Thermal release of
zeolite is conducive in hemostasis, but losing
control will cause serious burns. How to balance the advantages and
disadvantages is a challenge. Herein, a zeolite/cross-linked graphene
sponge (Z-CGS) was design to break through this challenge. The CGS
managed the heat release of zeolite by thermal conduction of graphene.
Infrared thermal imager demonstrated the mild exothermic process and
good thermal conductivity of the optimized Z-CGS. It controlled wound
temperature below 42 °C effectively, as compared to 70 °C
of naked zeolite. Blood clotting index further confirmed the contribution
of thermal stimulation in Z-CGS. On the synergy of thermal and charge
stimulations of zeolite, as well as physical adsorption of CGS, Z-CGS
achieved outstanding hemostatic performance. Bleeding was stopped
within 69 s in rat artery injury model, faster than that of the Quikclot
Combat Gauze. Additionally, cytotoxicity assay and pathological analysis
highlighted its biocompatibility. Z-CGS, therefore, was an outstanding
composite of combining advantages of zeolite and graphene, while getting
rid of the shortcomings of the basic unit. The thermal conductibility
of graphene renews an avenue for the safe and highly efficient use
of zeolite in hemostasis.
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Liang, Yuping; Xu, Congcong; Liu, Fang; Du, Shiyu; Li, Guofeng; Wang, Xing (2019). Eliminating
Heat Injury of Zeolite in Hemostasis via
Thermal Conductivity of Graphene Sponge. ACS Publications. Collection. https://doi.org/10.1021/acsami.9b04956
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AUTHORS (6)
YL
Yuping Liang
CX
Congcong Xu
FL
Fang Liu
SD
Shiyu Du
GL
Guofeng Li
XW
Xing Wang