Electrosynthesis
of Protected Dehydroamino Acids

Christmann, Mathias

Electrosynthesis of Protected Dehydroamino Acids

Posted on 2023-03-23 - 19:35

A NaCl-mediated electrochemical oxidation of amino acid carbamates (R¹ = Boc, Cbz) afforded α-methoxylated α-amino acids. Subsequent acid-catalyzed elimination delivered valuable dehydroamino acid derivatives. The simplicity of our setup using graphite-electrodes was showcased, producing N-Boc-ΔAla-OMe on a decagram scale.

CITE THIS COLLECTION

Gausmann, Marcel; Kreidt, Nadine; Christmann, Mathias (2023). Electrosynthesis of Protected Dehydroamino Acids. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.3c00403

https://doi.org/10.1021/acs.orglett.3c00403

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