Electrochemical-Promoted Nickel-Catalyzed Oxidative
Fluoroalkylation of Aryl Iodides
Posted on 14.10.2021 - 02:43
This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides under electrochemical conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.
CITE THIS COLLECTION
Zou, Zhenlei; Li, Heyin; Huang, Mengjun; Zhang, Weigang; Zhi, Sanjun; Wang, Yi; et al. (2021): Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.1c02997
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valent nickel catalystscatalyzed oxidative fluoroalkylationpromoted nickelcatalyzed crosswork describeswell addressedpaired electrolysisgeneral strategyfluoroalkyl sulfinatesfluoroalkyl radicalsfluorinated functionalitiesdirect introductioncathodic reductionaryl iodidesaryl halidesaromatic systemsanodic oxidation