Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd<sup>0</sup>‑Catalyzed Asymmetric C(sp<sup>3</sup>)–H Activation
Published on 2019-01-11T20:14:39Z (GMT) by
A divergent enantioselective synthesis of (nor)illudalane sesquiterpenes was designed by using a Pd<sup>0</sup>-catalyzed asymmetric C(sp<sup>3</sup>)–H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the target molecules. A matched combination of chiral substrate and catalyst proved optimal to reach good levels of stereoselectivity. This approach enabled the synthesis of three (nor)illudalanes, including (<i>S</i>)-deliquinone and (<i>S</i>)-russujaponol F, which are synthesized for the first time in enantioenriched form.
Cite this collection
Melot, Romain; Craveiro, Marcus V.; Bürgi, Thomas; Baudoin, Olivier (2019): Divergent Enantioselective Synthesis of (Nor)illudalane
Sesquiterpenes via Pd0‑Catalyzed Asymmetric C(sp3)–H Activation. ACS Publications. Collection.