Direct Lactonization of Alkenols via
Osmium Tetroxide-Mediated Oxidative
Cleavage

Borhan, Babak

Direct Lactonization of Alkenols via Osmium Tetroxide-Mediated Oxidative Cleavage

Posted on 2003-07-29 - 00:00

A highly efficient, mild, and simple protocol is presented for the tandem OsO₄-mediated oxidative cleavage/oxidative lactonization of alkenols to lactones. The protocol couples the OsO₄-catalyzed oxidative cleavage of olefins with Oxone as the co-oxidant with the direct oxidation of aldehydes in alcoholic solvents to their corresponding esters.

CITE THIS COLLECTION

Schomaker, Jennifer M.; Travis, Benjamin R.; Borhan, Babak (2016). Direct Lactonization of Alkenols via Osmium Tetroxide-Mediated Oxidative Cleavage. ACS Publications. Collection. https://doi.org/10.1021/ol035057f

https://doi.org/10.1021/ol035057f

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