Direct Assembly and Metal-Ion Binding Properties of
Oxytocin Monolayer on Gold Surfaces
Posted on 2019-08-08 - 19:44
Peptides
are very common recognition entities that are usually
attached to surfaces using multistep processes. These processes require
modification of the native peptides and of the substrates. Using functional
groups in native peptides for their assembly on surfaces without affecting
their biological activity can facilitate the preparation of biosensors.
Herein, we present a simple single-step formation of native oxytocin
monolayer on gold surface. These surfaces were characterized by atomic
force spectroscopy, spectroscopic ellipsometry, and X-ray photoelectron
spectroscopy. We took advantage of the native disulfide bridge of
the oxytocin for anchoring the peptide to the Au surface, while preserving
the metal-ion binding properties. Self-assembled oxytocin monolayer
was used by electrochemical impedance spectroscopy for metal-ion sensing
leading to subnanomolar sensitivities for zinc or copper ions.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Mervinetsky, Evgeniy; Alshanski, Israel; Buchwald, Jörg; Dianat, Arezoo; Lončarić, Ivor; Lazić, Predrag; et al. (2019). Direct Assembly and Metal-Ion Binding Properties of
Oxytocin Monolayer on Gold Surfaces. ACS Publications. Collection. https://doi.org/10.1021/acs.langmuir.9b01830
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (11)
EM
Evgeniy Mervinetsky
IA
Israel Alshanski
JB
Jörg Buchwald
AD
Arezoo Dianat
IL
Ivor Lončarić
PL
Predrag Lazić
ZC
Željko Crljen
RG
Rafael Gutierrez
GC
Gianaurelio Cuniberti
MH
Mattan Hurevich
SY
Shlomo Yitzchaik
KEYWORDS
Gold Surfaces Peptidesmultistep processesMetal-Ion Binding PropertiesDirect Assemblyelectrochemical impedance spectroscopyOxytocin Monolayercopper ionsforce spectroscopyspectroscopic ellipsometrySelf-assembled oxytocin monolayerdisulfide bridgemetal-ion binding propertiesgold surfacerecognition entitiespeptideX-ray photoelectron spectroscopyoxytocin monolayersubnanomolar sensitivities